FORMULATION AND EVALUATION OF BILAYERED TABLET OF ATORVASTATIN

B. Kalpana*, P. Prasuna Sundari and Dr. M. Bhagavan Raju

ABSTRACT

Piperine is an alkaloid isolated from piper nigrum Linn (family: piperaceae) a natural bioenhancer. It enhances the bioavailability of drugs by inhibiting cytochrome p450 enzyme. Atorvastatin is a lipid lowering agent. It has approximately 12% bioavailability. Hence, the objective of present study is to enhance bioavailability of atorvastatin using piperine as a bioenhancer. The study was carried out to formulate bilayered tablets of atorvastatin with different concentration of piperine using superdisintegrants (sodium starch glycolate, croscarmellose sodium, crospovidone) by direct compression method. The prepared formulation was subjected to evaluation for hardness, weight variation, friability, content uniformity, invitro release studies. Among all the formulation F3 containing piperine (15mg), sodium starch glycolate, microcrystalline cellulose and magnesium stearate is considered as the best formulation when compared to all other formulations and compared with the marketed formulation of atorvastatin (Lipitor)

Keywords: Piperine, Bioenhancer, Atorvastatin, Bioavailability.