DEVELOPMENT AND VALIDATION OF A STABILITY-INDICATING METHOD FOR THE SIMULTANEOUS DETERMINATION OF SAXAGLIPTIN HYDROCHLORIDE AND DAPAGLIFLOZIN PROPENEDIOL MONOHYDRATE IN QTERN® BY REVERSED-PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY
Parbati Kirtania* and Dr. Neemala Appalaraju
ABSTRACT
High performance liquid chromatography (HPLC) is commonly used for the separation and identification of compounds in a sample. Reversed-phase HPLC (RP-HPLC) is the most commonly used separation mechanism in liquid chromatography. This mechanism consists of a polar mobile phase and a non-polar stationary phase. The purpose of this research was to develop a simple, fast, precise and accurate RP-HPLC stability-indicating method that can be applied to the drug Qtern®, as it contains both Saxagliptin Hydrochloride and Dapagliflozin Propenediol monohydrate.
Keywords: Reversed-phase HPLC (RP-HPLC), Saxagliptin Hydrochloride, Dapagliflozin Propenediol monohydrate, Chromatograms and Chromatographic conditions.
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