EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

ANTI-CANCER ACTIVITY OF AQUILARIA MALACENSIS LEAVES ON HUMAN CERVICAL CANCER CELLS

Fatmawati and Rachmat Hidayat*

ABSTRACT

Background: Recent studies have shown that anti-oxidant and herbal derivatives may be effective against prevailing high risk human papilomavirus infection but these leads are yet to prove their efficacy in preclinical and subsequent clinical studies. Aquilaria malacensis belongs to the, locally known as gaharu are reported to contain more than a dozen chemical constituents The stem of Aquilaria sinensis, another species of Aquilaria, reported to possess anti-cancer activity Moreover, the pesence of glycoside moieties like saponins, antraquinones, steroidal glycosides and flavonoids could inhibit tumor growth. Methods: The leaves of Aquilaria malacensis were extracted and fractionated to get fractionn-hexane, ethylacetate and etanol-aquadest. Cytotoxic activity of every fraction was assayed with MTT assay in HeLa cell culture. Phytochemical assay was done to explore chemical constituent in every fraction. Results: Fraction ethylacetate and n-hexane had the same potential to inhibit cervical cancer growth from concentration 15,63 μg/ml to 125 μg/ml. In the concentration more than 125 μg/ml, The potention to inhibit cervical cancer cell growth increased for fraction n-hexane but the potention decreased for fraction ethylacetate. The inhibitory concentration 50% (IC 50) for fraction n-hexane was 163 μg/ml. Conclusion: Our study therefore demonstrates presence of anticancer in gaharu leaves that can be further exploited as a potential anticancer.

Keywords: Aquilaria- Fraction – HeLa Cell- Anti cancer.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )