EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

ALTERATIONS IN HISTO-ARCHITECTURE OF SELECTED TISSUES IN CO-ADMINISTRATION OF IPOMOEA BATATA EXTRACT AND ANTI-OXIDANT VITAMIN TO DIABETIC WISTAR RATS

*A. A. Aigbiremolen, O. M. Odigie, I. O. Iribhogbe and C. P. Aloamaka

ABSTRACT

Reports on the importance of potato leaf (Ipomoea Batata) extract on various physiological systems of the human body are rife; with most showing it to be medicinal, pharmacological, and efficacious in the management of disease conditions, including blood related ailments. However, little or no record(s) have detailed its hypoglycaemic effect on body weights in relation to changes in the histo-architecture of selected tissues. Current study examined the effect of Ipomoea Batata leaf aqueous extract on blood sugar levels, body weights and histology of selected visceral [pancreas, liver and kidney]; in alloxan induced diabetic wistar rats. Twenty five (25) healthy Wistar rats of an average weight of between 140 – 200g were procured from the animal unit of the Ambrose Alli University, Ekpoma, Edo State. They were then acclimatized for two (2) weeks and randomly grouped into five (5) [G1, G2, G3, G4 and G5]; G1 (Control) received standard rat diets ad libitum, While G2 was fed daily with calculated doses of aqueous extract of sweet potato leaf per kg body weight after inducing diabetes mellitus (DM) with alloxan monohydrate. G3 and G4 (DM induced) were orally given (by mixing with diets, daily for two weeks) vitamin C and extract + vitamin C (Co-administration) respectively, group 5 (G5) received calculated doses of extract + vitamin E per kg body weight for 2weeks. For each group, Body weights were checked weekly, at the end of which animals were sacrificed with their liver, pancreas and kidneys harvested for histo-architectural changes. Blood samples were also obtained (using cardiac puncture) for analysis of changes in glucose levels. Following comparison (using the student t-test), study found a statistically significant increase (p < 0.05) in body weights and blood sugar levels of experimental groups [G2 – G5] compared with control [G1]; study also observed ameliorative changes in pancreatic, liver and renal histo-architectures (using H and E x 40) of DM induced rats as against non-diabetic (control) rats.

Keywords: Ipomoea Batata, haematological indices, Wistar rats.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )