DEVELOPMENT OF FAST DISINTERGRATING TABLET (FDT) LEAF EXTRACT Graptophyllum pictum L. Griff WITH VARIATION OF Ac-Di-Sol CONCENTRATION AND SWEET TYPE

Nhadira Nhestricia*, Lily Elfrida, Erni Rustiani, Riska Handayani

ABSTRACT

Graptophyllum pictum L. Griff have traditionally been used for generations and a lot of research has been done to develop these plants. This plant contains nutritious chemical compounds such as alkaloids, flavonoids, saponins, tannins, triterpenoids, steroids, and glycosides. Fast Disintegrating Tablet (FDT) is a tablet that is easy to use without the need to use drinking water. FDT is designed to be destroyed quickly without chewing and without the aid of water for no more than 3 minutes (Bhowmik et al., 2009). This study aims to determine the type of sweetener favored by panelists with a concentration of Ac-Di-Sol 3%. Sweeteners for Formula 1 (sucralose) and formula 2 (aspartame). Tablet quality parameters include organoleptic, uniformity of weight, uniformity of size, hardness, friability, time of in vitro dispersion, hedonic test, and determination of flavonoid levels of Graptophyllum pictum extract and the best formulation of tablet formulas. The results of tablet quality testing on each formula showed a grayish black tablet, flat round shape with a flat bottom surface and top surface had a diameter, aromatic distinctive odor, had a sweet taste at the beginning of contact with saliva but in a long time gave bitter taste on the tongue. Tablet quality evaluations for all formulas meet the requirements of Pharmacopoeia III and IV. The results of this study indicate that formula 1 is the best formula for extracting Graptophyllum pictum extract with sweetener sucralose.

Keywords: Purple plants, FDT, sucralose, aspartame.