EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Scope Database , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

DEVELOPMENT OF FAST DISINTERGRATING TABLET (FDT) LEAF EXTRACT Graptophyllum pictum L. Griff WITH VARIATION OF Ac-Di-Sol CONCENTRATION AND SWEET TYPE

Nhadira Nhestricia*, Lily Elfrida, Erni Rustiani, Riska Handayani

ABSTRACT

Graptophyllum pictum L. Griff have traditionally been used for generations and a lot of research has been done to develop these plants. This plant contains nutritious chemical compounds such as alkaloids, flavonoids, saponins, tannins, triterpenoids, steroids, and glycosides. Fast Disintegrating Tablet (FDT) is a tablet that is easy to use without the need to use drinking water. FDT is designed to be destroyed quickly without chewing and without the aid of water for no more than 3 minutes (Bhowmik et al., 2009). This study aims to determine the type of sweetener favored by panelists with a concentration of Ac-Di-Sol 3%. Sweeteners for Formula 1 (sucralose) and formula 2 (aspartame). Tablet quality parameters include organoleptic, uniformity of weight, uniformity of size, hardness, friability, time of in vitro dispersion, hedonic test, and determination of flavonoid levels of Graptophyllum pictum extract and the best formulation of tablet formulas. The results of tablet quality testing on each formula showed a grayish black tablet, flat round shape with a flat bottom surface and top surface had a diameter, aromatic distinctive odor, had a sweet taste at the beginning of contact with saliva but in a long time gave bitter taste on the tongue. Tablet quality evaluations for all formulas meet the requirements of Pharmacopoeia III and IV. The results of this study indicate that formula 1 is the best formula for extracting Graptophyllum pictum extract with sweetener sucralose.

Keywords: Purple plants, FDT, sucralose, aspartame.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database