IMMUNE DEFENSE MECHANISMS FOR CERVICAL INTRAEPITHELIAL NEOPLASIA

*Kalandarova A. N.

ABSTRACT

The results of a comprehensive survey of 111 women of reproductive age with varying degrees of CIN residing were studied in the Republic of Karakalpakstan. From surveyed women, CIN I - was detected in 45, who made up the 1st group, CIN II - in 35 women - the 2nd group, and 31 women with CIN III - the 3rd group. Immunological studies were conducted by studying some parameters of the cellular (CD3, CD4, CD8, CD16, CD20, CD25, CD95) humoral (IgG, IgA, IgM) and cytokine (IL-1b, IL-6, TNFα and IFNγ) status. The following research methods were used: clinical, ultrasound, endoscopic (colposcopy), cytological, immunological, bacterioscopic, bacteriological, PCR. It was revealed that the severity of immunological disorders is correlated with the nature of pathological changes in cervical intraepithelial tissue, which indicates the involvement of the immune system in the pathogenesis of CIN.

Keywords: Cervical intraepithelial neoplasia, immunity, immunocorrection.