SYNTHESIS AND EVALUATION OF ANTICANCER ACTIVITY OF SOME NEW SCHIFF BASES OF AMINO-THIOPHENE DERIVATIVES
Mokhtar Abd-Hafiz Al-Ghorafi*, Aliaa Mohamed Kamal, Jalal H. Abdullah, Tawfeek Ahmed Ali Yahya, Shada H. Yassin
A new series of amino-thiophene Schiff bases (IIa-i) was synthesized and characterized using spectroscopic methods. Schiff bases were prepared via condensation reactions of different aromatic aldehydes and amino-thiophene. All Schiff bases were tested against MCF7 and HCT116 cell lines, the imine compounds exhibited selectivity excellent cytotoxic for aforementioned carcinoma cell lines. Especially, compound IIc and IIh were the most active compounds against both cell lines, it is well known that, the difference in the characteristics of substituents attached to the Schiff base function leads to interesting variations within pharmacological actiivty of resultant molecular systems.
Keywords: Schiff Bases, Anti-cancer activity, Thiophene.
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