EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Scope Database , Academia ,

ISSN 2394-3211

Impact Factor: 6.222

ICV - 79.57

Abstract

SYNTHESIS AND EVALUATION OF ANTICANCER ACTIVITY OF SOME NEW SCHIFF BASES OF AMINO-THIOPHENE DERIVATIVES

Mokhtar Abd-Hafiz Al-Ghorafi*, Aliaa Mohamed Kamal, Jalal H. Abdullah, Tawfeek Ahmed Ali Yahya, Shada H. Yassin

ABSTRACT

A new series of amino-thiophene Schiff bases (IIa-i) was synthesized and characterized using spectroscopic methods. Schiff bases were prepared via condensation reactions of different aromatic aldehydes and amino-thiophene. All Schiff bases were tested against MCF7 and HCT116 cell lines, the imine compounds exhibited selectivity excellent cytotoxic for aforementioned carcinoma cell lines. Especially, compound IIc and IIh were the most active compounds against both cell lines, it is well known that, the difference in the characteristics of substituents attached to the Schiff base function leads to interesting variations within pharmacological actiivty of resultant molecular systems.

Keywords: Schiff Bases, Anti-cancer activity, Thiophene.

[Full Text Article]

SJIF Impact Factor: 6.222

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NEWS & UPDATION

EJPMR: DECEMBER ISSUE PUBLISHED
December issue has been successfully launched on 1 December 2023.

New Issue Published
Its Our pleasure to inform you that, EJPMR 1 December 2023 Issue has been Published, Kindly check it on https://www.ejpmr.com/issue

EJPMR New Impact Factor
Its our Pleasure to Inform you that EJPMR Impact Factor has been increased from 5.804 to 6.222, due to high quality Publication at International Level