EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

COMPARATIVE STUDY OF THREE ANTIRETROVIRAL DRUGS ON LIVER ENZYMES (ALANINE AMINOTRANSFERASE, ASPARTATE AMINOTRANSFERASE AND ALKALINE PHOSPHATASE)

George Adieboye Oforibika* and Augustine Amadikwa Uwakwe

ABSTRACT

This study comparatively evaluate the effects of nevirapine (nevran), lamivudine and zidovudine on alanine aminotransferase (ALT), aspartate aminotransferase (AST) and alkaline phosphatase (ALP) activities of normal albino rats. A total of 63 albino rats were randomly divided into 5 groups labelled A, B, C, D and E and kept in a well ventilated room. Group A served as control and these rats were treated with distilled water. Rats in the groups B, C, D and E were treated with 4 different doses of the drugs (0.7, 1.4, 2.1 and 2.8mg/Kgbw) respectively. The drugs were administered once daily for 1, 2, 3, 4 and 5 weeks consecutively. Animals were sacrificed 24 hours after the last treatment. Blood samples were collected into heparinized sample bottles for analysis. Results obtained revealed that AST levels were highest in Nevran at week 3 of group B (178.00±1.15 IU/L) when compared to the control (122.6±8.45IU/L). Significant differences (p<0.05) existed among the 3 drugs at group B of week 1 and there was no significant differences between any at group E of week 5. Lamivudine had the highest activity for ALT at group D of week 3(80.00±1.15IU/L) as compared to the control (44.67±2.60IU/L). Nevran and zidovudine were significantly different with the other drugs at group B of week 1 and group E of week 5. Mean ALP activity was greatest in Lamivudine at group C of week 1 (58.20±0.06IU/L) when compared to the control (46.73±3.54IU/L). There was no significant difference (p>0.05) between any drug at group B of week1 while at group E of week5 Lamivudine was significantly different (p<0.05) with the other drugs. Treatment of HIV/AIDS with ARVs could result to liver damage by hepatocellular injury or by necrosis of the liver due to prolonged treatment.

Keywords: Antiretroviral drugs (ARVs), albino rats, HIV/AIDS, hepatocellular injury, liver.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )