EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

EVALUATION OF THE POSSIBLE PROTECTIVE EFFECTS OF CAPTOPRIL AND VALSARTAN ON METHOTREXATE-INDUCED HEPATOTOXICITY IN ALBINO RATS

Sanaa A. Ahmed*, Wafaa A. Abd Elaa and Mayada M. Ahmed

ABSTRACT

The aim of this study was to evaluate the ameliorating effect of both captopril and valsartan on methotrexate (MTX)-induced hepatotoxicity in rats. Forty two adult male albino rats weighing 180-250 g were divided into 6 groups; n= 7. Groups 1, 2, and 3 were orally received saline (control), captopril (20 mg/kg/day) and valsartan (30 mg/kg/day) respectively for 3 weeks. Groups 4, 5, and 6 were orally pretreated with saline (toxicity control), captopril and valsartan respectively in the same doses and duration as three previous groups. At the end of treatment, groups 4, 5, and 6 were subjected to single dose of MTX 5 mg/kg I.P. The impacts of MTX on the hepatic injury and its prevention by captopril and valsartan were assessed by estimation of serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), total bilirubin (T.Bil), total protein and albumin. In addition, superoxide dismutase (SOD) activity, nitric oxide (NO), malondialdehyde (MDA) levels were measured in serum and liver homogenates. MTX resulted in significant increases (P < 0.01) in AST, ALT T.Bil, NO and MDA levels and decrease in serum albumin and protein levels and SOD activity; as well as severe congestion and inflammation in liver tissues compared to control group. On the other hand, pre-treatment with captopril or valsartan decreased MTX-induced alterations in liver function, NO, and MDA levels and SOD activity; also, ameliorated the induced changes in liver tissues. The oxidative stress plays an essential role in MTX-induced hepatotoxicity in rats. Captopril and valsartan have a protective effect on MTX-induced hepatotoxicity; which may be created by their antioxidant effect.

Keywords: Captopril, Valsartan, Methotrexate, Hepatotoxicity, SOD and NO.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )