EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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ISSN 2394-3211

Impact Factor: 7.065

ICV - 79.57

Abstract

ANALYSIS OF INTRAVITREAL ADMINISTRATION OF STEREOISOMERIC FORM OF BETAXOLOL IN RABBIT MODEL

A. Vikneswari* and T. Tamizh Mani

ABSTRACT

Many of the drugs currently used in ophthalmic practice are enantiomers. The majority of ophthalmic medications are formulated as eye drops. β -blockers decrease aqueous humor production by approximately one-third. To obtain the desired lowering in IOP, large quantity of conventional eye drops of betaxolol hydrochloride is used. Twelve New Zeland albino male rabbits weighing 2.3 to 3 kg were selected for this study. Animals were randomized into 3 groups of 2 each. All three groups were used to evaluate intravitreal drug disposition of betaxolol Hydrochloride, R-betaxolol and S betaxolol respectively. The drug distribution profile of betaxolol was studied. The result shows that the drug distribution after intravitreal injection is more in the enantiomeric form than the racemic form of betaxolol.

Keywords: Betaxolol, intravitreal, HPLC.

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