SYNTHESIS OF SOME CHALCONES AND PYRAZOLINES CONTAINING ?-NAPHTHOL AS ANTICANCER AGENTS
Shada H. Yassin, Tawfeek A. Yahya* and Jalal H. Abdullah
A series of pyrazolines (5a-d) were synthesized by reaction of chalcones (4a-d) with thiosemicarbazide. The pyrazoline (5b) (IC50, 8.02) showed moderate anticancer activity (IC50= 8.02 μM) when compared to standard drug doxorubicin (IC50= 5.04 μM).
Keywords: Chalcone, pyrazoline, thioamide, ?-naphthol, anticancer.
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