EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

PIOGLITAZONE-INDUCED PULMONARY OEDEMA IN POST MASTECTOMY PATIENT

Aby Paul*, Swapna Saju, Dona Johnson, Neethu Mariyam Johny and Jobin Kunjumon Vilapurathu

ABSTRACT

Pioglitazone is a commonly used anti diabetic drug. It is a proven insulin sensitizer which lowers the glucose level in the blood. Here we report a case of patient who suffered pulmonary oedema with normal cardiac functioning due to the use of pioglitazone. A 87 year old, female, who had a history of breast cancer (stage 1), and underwent mastectomy (right breast) along with several cycles of chemotherapy one year back. She was diabetic for the past 24 years and is on oral hypoglycaemic agents (OHA). The patient also had a history of Hypertension since 12 years; she was on antihypertensive. The patient got admitted in the emergency department with breathlessness and pedal oedema. All blood parameters except potassium levels were normal. Cardiac markers (d-dimer and troponins) were on the normal range, ECG leads was also normal. Chest X-ray revealed pulmonary oedema with effusion in both lungs. Computed tomography of chest showed dilated pulmonary arteries along with glassy round patches as a classical symptom of pulmonary oedema. Although the patient was treated with intravenous antibiotics and other supportive care, repeated chest X ray didn’t showed any improvement. Hence pioglitazone was suspected as a potential cause and was discontinued in the same day. The patient’s conditions improved in the following days. Chest X-ray repeated on the sixth day showed clinical improvement. Hence we conclude that all patients in the aged population and with or without a compromised cardiac function have to be monitored closely to prevent such adverse events due to pioglitazone.

Keywords: .


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )