NOVEL LONG RETENTIVE MUCOADHESIVE POSACONAZOLE OPHTHALMIC SUSPENSION DEVELOPMENT WITH HELP OF SODIUM ALGINATE AND CARRAGEENAN POLYMER SYSTEM
Jadhav Simta*, Inamdar Kavita and Bhitre Milind
In consideration of eye fungal infection limited research there is need for development of antifungal ophthalmic suspension. Instilled ophthalmic formulations bioavailability is generally less due to rapid tear drainage and blinking of eyes. The objective of present work was to develop long retentive posaconazole ophthalmic suspension using sodium alginate and carrageenan which was pre-identified by means of experimental design study. Sodium alginate is generally used in sol gel ophthalmic formulation is ready to use long retentive mucoadhesive formulation. The developed formulations were characterized for homogeneity, pH, particle size, viscosity, osmolality, rheology study, mucoadhesive strength, contact angle, assay of posaconazole and benzalkonium chloride, degradation product, in vitro drug release, eye irritation test and pharmacodynamic efficacy. A stable long retentive posaconazole ophthalmic formulation was developed based on principles of quality by design and as per industrial standards.
Keywords: Sodium alginate, Carrageenan, Polymer, long retentive, posaconazole, ophthalmic suspension.
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