EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

A PROSPECTIVE OBSERVATIONAL STUDY ON UTILISATION OF VANCOMYCIN IN PAEDIATRIC INPATIENTS IN TERITIARY CARE HOSPITAL

*Thanneeru Vishnupriya, Pharm-D, Ganta Jahnavi, Pharm-D, Bandi Shashi Kumar, Pharm-D, Dr. Gonepally Vaishnavi, Pharm-D and Padma Padma, Pharm-D

ABSTRACT

Vancomycin is a glycopeptide antibiotic used to treat number of various disease conditions(especially bacterial infections). Vancomycin is frequently inappropriately prescribed, especially as empirical treatment. It is considered appropriate for treating beta lactum resistant gram positive microorganisms, but is inappropriate for beta lactum susceptible microorganisms unless the patient is severely allergic to beta lactum antimicrobials. Aims and Objectives: To study the empirical use of vancomycin in hospitalized pediatric patients and to optimize the inappropriate prescribing patterns of vancomycin. Methodology: This prospective study was conducted over a period of 6months in 2018 to identify the inappropriate vancomycin prescription in hospitalized pediatric patients in tertiary care hospitals. The necessary data was collected from the inpatient case notes, treatment charts, patient attendants, and nursing staff. The data was analysed based on the culture sensitivity reports, indications for vancomycin prescription, duration of therapy with vancomycin, chances for drug interactions, vancomycin dosing consideration. Results: In our study, it was found that out of 166 patients, 138 (83.13%) patients were treated with vancomycin empirically and in 28 (16.86%) patients vancomycin was given after specific diagnosis. Conclusion: Infants were mostly affected with various diseases. Therapy with vancomycin was continued even though the culture sensitivity reports did not necessitate the use of vancomycin. In such conditions therapy may be shifted to other antibiotics. In certain cases weight was not considered in vancomycin therapy. This may result in sub-optimal therapeutic outcomes or toxicity. We also found that majority of patients were treated with vancomycin empirically, even though its use was not really required.

Keywords: Vancomycin, Empirical treatment, Culture sensitivity tests, Paediatrics.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )