EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

FORMULATION AND EVALUATION OF METOPROLOL SUCCINATE NIOSOMAL GEL

Dr. C. Aparna*, R. Naga Sai Rupa and Dr. M. Bhagavan Raju

ABSTRACT

Self-assembly of non-ionic surfactants into vesicles was first reported in the cosmetic industry. Niosomes are osmotically active and stable, increase the stability of entrapped drug. The present study focuses on enhancement of bioavailability and sustaining the release rate of metoprolol succinate. Metoprolol succinate niosomes were formulated using different ratios of the span and cholesterol. The vesicles were evaluated for the encapsulation efficiency and drug release. The niosomes were characterized for surface morphology and particle size. SEM studies indicated that there was no aggregation and particles existed as separate entities with uniform size distribution. Among the niosomal formulations prepared, formulations B2 and B3 containing cholesterol and span60 in the ratios 1:1 and 1:3 were selected due to high entrapment efficiency (84% for B2 and 80% for B3), high drug release (82.74% for B2 69.52% for B3) and stability. The formulations B2 and B3 were formulated into niosomal gel using different concentrations of Carbopol 934. The gel formulation could sustain the drug release for 24hrs. Niosomes enhance the bioavailability of metoprolol succinate by avoiding the pre-systemic metabolism, and niosomal gels can sustain the release rate of metoprolol succinate and hence are a promising approach for delivery of drug through transdermal route.

Keywords: Metoprolol succinate, niosomes, niosomal gel, prolonged drug release.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )