OCULAR DRUG DELIVERY SYSTEM: A REVIEW

Harpreet Kaur*, Sandeep Kumar, Satvir Singh and Chamanpreet Kaur

ABSTRACT

Topical administration for ocular therapeutics is ideal because of smaller doses required compared to the systemic use, its rapid onset of action and freedom from systemic toxicity Topically applied ocular drugs have to reach the inner parts of the eye and transcorneal penetration is believed to be the major route for drug absorption. Corneal absorption is much slower process than elimination. The specific aim of designing a therapeutic system is to achieve an optimal concentration of a drug at the active site for the appropriate duration. Ideal ophthalmic drug delivery must be able to sustain the drug release and to remain in the vicinity of front of the eye for prolong period of time. Consequently it is imperative to optimize ophthalmic drug delivery; one of the way to do so is by addition of polymers of various grades, development of in situ gel or colloidal suspension or using erodible or non erodible insert to prolong the pre corneal drug retention. This review focused on controlled and sustained drug delivery has become the standard in modern pharmaceutical design and several possible routes of drug delivery into the ocular tissues.

Keywords: Ophthalmic drug delivery, Corneal drug delivery, Controlled and sustained drug delivery.