EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Scope Database , Academia , 

 ISSN 2394-3211

Impact Factor: 7.065

 ICV - 79.57

Abstract

SEMINAL MALONDIALDEHYDE LEVEL: AN OXIDATIVE STRESS MARKER IN INFERTILE MALES IN NORTH CENTRAL PART OF NIGERIA

*Olaniru Olumide, Adoga Godwin, Johnson Tililayo, Pam Ishaya, Ochalefu Dickson, Obeta Uchejeso

ABSTRACT

Aim: To evaluate the association between oxidative stress and male infertility with sperm quality and malondialdeyde concentration. Background: Infertility is a major problem affecting approximately 30% of the male population. Apart from known factors, it becomes very important to identify new and nonconventional factors that may play significant roles in male infertility. Oxidative stress has recently been identified as an underlying mechanism of numerous chronic diseases of which male infertility has been claimed to have a relationship. Materials and methods: A cross sectional prospective study of 80 (30 fertile and 50 infertile) men with age range between 25-50 years were enrolled in the study. WHO guidelines was used in seminalysis and thiobarbituric acid method for malondialdeyde analysis. Results: The mean ± SD malondialdehyde (MDA) concentration in seminal plasma of infertile men (3.3 ± 0.4 nmol/ml) was significantly higher than fertile men (2.4 ± 0.2nmol/ml) (P-value ˂ 0.05) and had a negative relationship with sperm count. Conclusion: This study revealed that high level of MDA was associated with increase in lipid peroxidase with sperm membrane destruction.

Keywords: Seminal plasma, Male infertility, Sperm count, Lipid peroxidase, Malon dialdehyde (MDA).


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database Academia