ASSESSMENT OF HEREDITARY WEARING IN CHILDREN WITH CHRONIC BRONCHOPULMONARY PATHOLOGY

*Masharipova M. S. and Fayzullaeva N. Ya.

ABSTRACT

Background: Hereditary lung diseases represent one of the most complex diagnostic, pathogenetic and therapeutic problems of modern pulmonology. Currently, due to the expansion of clinical and diagnostic capabilities for monitoring the effectiveness of various therapeutic effects and the growth dynamics of bronchopulmonary pathology in children, the study of heredity in the occurrence of chronic respiratory diseases is of particular importance, which will improve their early detection in risk groups using modern high-tech methods and diagnostic tools. Objective: Determine the genetic predisposition of chronic bronchitis in schoolchildren in Uzbekistan. Methods: To fulfill the goal of the thesis, 150 sick children with chronic diseases of the bronchopulmonary system were selected, who received treatment in the pulmonology department of the Republican Specialized Scientific and Practical Center of Pediatrics of the Ministry of Health of the Republic of Uzbekistan and the Bukhara Regional Children's Multidisciplinary Medical Center. Results: Genotyping results based on the case-control analysis method showed that among children with chronic bronchitis a heterozygous carriage of mutations of the CFTR_F508del / n, CFTR_W1282X / n, CFTR_W1282X / n, CFTR_N1303K / n gene was detected. Mutation CFTR_F508del / n was detected in 6.25% (3 children), CFTR_W1282X / n in 2.1% (1 child), CFTR_N1303K / n in 2.1% (1 child). Conclusion: Thus, the association of markers F508del, W1282X, N1303K of the CFTR gene established in our studies confirms the data of various authors that in patients with severe chronic diseases of the respiratory tract and lungs, mutations of the CFTR gene, especially the deletion of F508 in the heterozygous state, have been increasingly found recently (T.E. Ivashchenko, V.S. Baranov, 2002).

Keywords: Chronic bronchitis, children, the CFTR gene mutation.