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 ISSN 2394-3211

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*Masharipova M. S. and Fayzullaeva N. Ya.


Background: Hereditary lung diseases represent one of the most complex diagnostic, pathogenetic and therapeutic problems of modern pulmonology. Currently, due to the expansion of clinical and diagnostic capabilities for monitoring the effectiveness of various therapeutic effects and the growth dynamics of bronchopulmonary pathology in children, the study of heredity in the occurrence of chronic respiratory diseases is of particular importance, which will improve their early detection in risk groups using modern high-tech methods and diagnostic tools. Objective: Determine the genetic predisposition of chronic bronchitis in schoolchildren in Uzbekistan. Methods: To fulfill the goal of the thesis, 150 sick children with chronic diseases of the bronchopulmonary system were selected, who received treatment in the pulmonology department of the Republican Specialized Scientific and Practical Center of Pediatrics of the Ministry of Health of the Republic of Uzbekistan and the Bukhara Regional Children's Multidisciplinary Medical Center. Results: Genotyping results based on the case-control analysis method showed that among children with chronic bronchitis a heterozygous carriage of mutations of the CFTR_F508del / n, CFTR_W1282X / n, CFTR_W1282X / n, CFTR_N1303K / n gene was detected. Mutation CFTR_F508del / n was detected in 6.25% (3 children), CFTR_W1282X / n in 2.1% (1 child), CFTR_N1303K / n in 2.1% (1 child). Conclusion: Thus, the association of markers F508del, W1282X, N1303K of the CFTR gene established in our studies confirms the data of various authors that in patients with severe chronic diseases of the respiratory tract and lungs, mutations of the CFTR gene, especially the deletion of F508 in the heterozygous state, have been increasingly found recently (T.E. Ivashchenko, V.S. Baranov, 2002).

Keywords: Chronic bronchitis, children, the CFTR gene mutation.

[Full Text Article]




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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database Academia