EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Scope Database , Academia , 

 ISSN 2394-3211

Impact Factor: 7.065

 ICV - 79.57

Abstract

A PARTIALLY PURIFIED LIPOPOLYSACCHARIDE EXTRACTED FROM KLEBSIELLA PNEUMONIA AS ANTIBACTERIAL

Ruaa SH.*, Suhad Mohammad and Esraa Sameer

ABSTRACT

50 isolates of Klebsiella pneumonia were isolated from150 urine specimens taken from recurrent –urinary tract infections (UTI) patients attended to AL-Sadar Hospital. Specimens were cultured on specific media, and then bacterial isolates were identified depending on morphological, biochemical and VITK-2. The results showed that Klebsiella pneumonia comprise 29 (58%), 5 (10%) and 16 (32%) from recurrent UTI, kidney stone and Catheters samples respectively. The isolate that appeared multidrug resistance(MDR) to most antibiotics used in this study were chosen to extracted lipopolysaccharide. The results of The antibacterial activity assay of LPS extract of Klebsiella pneumonia were done against E. coli, Klebsiella pneumonia, Proteus mirabilis, Salmonella typhi, Pseudomonas aeruginosa, Bacillus subtilis, Staph aureus, and Streptococcus pneumonia at different concentration (200,300,400) μg /ml were evaluated by measuring the diameters of zones of growth inhibition on bacterial, and compare with the inhibition zone of amoxicillin as control, the result show all bacteria sensitive to LPS (100%) at concentration (200,300,400) μg /ml and the inhibition zone ranging from (25 to33)mm, compare with amoxicillin that all bacteria resistance to it(100%). In Conclusion: LPS are promising a new medicine lead to kill gram positive and gram-negative bacteria.

Keywords: Lipopolysaccharide, Klebsiella pneumonia, urinary tract infection, amoxicillin, Antibiotics.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database Academia