( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57



P. R. C. Esegbue* and A. J. Uyovwiesevwa


In recent times, the increasing worldwide resort to coffee and caffeine consumption may not be unconnected with recent findings that it contains ingredients that promote male and female reproductive health. In view of this, current study investigated female reproductive health functions due to coffee administration to female wistar rats. Seventy (70) rats were procured and acclimatized (in two weeks) for the study. The rats were then grouped into seven (7) with experimental group 1 receiving standard rat diet and water ad libitum. Groups 2, 3 and 4 were respectively given 40mg/kg, 60mg/kg and 80mg/kg doses of Coffee; whereas, groups 5, 6 and 7 received 30mg/kg, 45mg/kg and 60mg/kg doses of Caffeine respectively. Following period of administration, rats were euthanized by cervical dislocation. Blood samples were then obtained (via cardiac puncture) and assayed for various reproductive hormones [Follicle Stimulating Hormone – FSH and Luteinizing Hormone - LH]. In any case, body weight and selected organ weights [Liver and Kidney] were also obtained and compared between coffee and caffeine treated rats at variable doses. Following comparison with student t-test, study found a statistically significant decrease (p < 0.05) in serum FSH and LH levels following the administration of caffeine and coffee to wistar rats at all doses. Study also found a statistically significant increase (p < 0.05) in relative liver weight in medium dose and high doses of Caffeine but only in high dose of coffee treatment when compared to control and high dose respectively. We recommend routine addition of caffeine, coffee’s active ingredient to dietary foods of females with low reproductive tendencies.

Keywords: Reproduction, Hormone, Coffee and Caffeine.

[Full Text Article]



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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )