EFFECT OF CONCURRENT CHEMO-RADIOTHERAPY IN THE MANAGEMENT OF CERVICAL CANCER: A PROSPECTIVE STUDY

Vutham Vilasini Soukya*, Vydehi Shivanathuni, Banda Anil, Durgam Sandya and Zeba Maheen

ABSTRACT

The present study was conducted to evaluate the effect of concurrent chemo-radiotherapy in the management of cervical cancer. The ability of radiotherapy to cure locally advanced cervical cancer is limited by the size of the tumor, because the doses required to treat large tumors exceed the limit of toxicity in normal tissue. Concurrent chemotherapy inhibits the repair of sub lethal damage from radiation, synchronizes cells to a particularly radiosensitive phase of the cell cycle, and is cytotoxic in vitro. The present study was conducted on 150 patients satisfying inclusion and exclusion criteria, the maximum number of patients are from stage-I has a frequency of 99% and a minimum number of patients are from stage IV with a frequency of 50%. Post-Operative patients has a frequency of 95%, stage II has a frequency of 90%, stage III has a frequency 85%. The results obtained from our studies show that early stage cervical cancer (<IIB) shows a better outcome of treatment of advanced stages (≥IIB). In the treatment of advanced stages (≥IIB), concomitant radio chemotherapy shows significant results in terms of complete tumor regression.

Keywords: Chemo-Radiotherapy, Cytotoxic, Tumor.