EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

PROTECTIVE EFFECT OF OCMUIM BASILICUM LEAVES EXTRACT ON DIAZINON-INDUCED REPRODUCTIVE TOXICITY AND OXIDATIVE STRESS IN ALBINO RATS

Saber A. Sakr* and Hany A. Abdelsamei

ABSTRACT

Objective: To evaluate the ameliorative role of the Basil (Ocmuim basilicum) leaves on the testicular damage induced by the organophosphorus insecticide, diazinon in albino rats. Methods: Animals were divided into four groups. Group I was considered as control. Group II was orally given aqueous O. basilicum extract at a dose level of 20 mg/ kg 5 days / week for 6 weeks. Group III was orally given diazinon at a dose of 20mg/ kg.b.wt, 5 days / week for 6 weeks. Group IV: rats were given diazinon followed by oral administration with aqueous O. basilicum extract 5 days/ week for 6 weeks. Animals were sacrificed after 3 and 6 weeks of treatment. Testes were removed and stained with H & E for histological examination and nuclear Ki-67 and bax were demonstrated. MDA, SOD and CAT activity in testes of different groups was evaluated. Results: Diazinon treatment caused many histopathological alterations, inhibition of spermatogenesis and morphometric changes in the testes. Immunohistochemical changes were detected as strong expression of bax in Leydig cells and decreased expression of Ki-67 in nuclei of spermatogonia. Lipid peroxidation marker, MDA was increased while the antioxidant enzymes namely SOD and CAT were decreased. Treating animals with diazinon and O. basilicum extract caused a reduction in testicular alterations caused by diazinon. Moreover, MDA decreased and SOD and CAT increased. Conclusion: The results of this study indicated that O. basilicum leaves extract lessens the reproductive alterations induced by diazinon in albino rats and this is may be due to the potent antioxidant effects of its components.

Keywords: Diazinon, Ocmuim basilicum, Testis, Histology, Oxidative stress.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )