IN VIVO EVALUATION OF ANTI-INFLAMMATORY AND ANTIOXIDANT POTENTIAL OF AQUEOUS EXTRACT OF ASTRAEUS HYGROMETRICUS ON ALBINO RATS
Sekhar Mandal, Shibani Basu, Tamoghna Maiti*, Ananya Mandal, Soumitra Mandal, Prasun Banerjee
Background and aims - Medicinal plants have been tested for their potential therapeutic effects. This study was
designed to screen the in vivo anti-inflammatory activity of Astraeus hygrometricus in acute inflammation.
Materials and methods – Anti-inflammatory activity was assessed by Carrageenan induced rat paw edema method.
Albino rats of either sex were divided in 5 groups (N=6) [Group-I – saline control; Group- II, III and IV aqueous
extracts of 200, 400, 600 mg/kg, P.O. respectively and Group- V Diclofenac1mg/kg, P.O. The paw volume was
measured initially at 0, 1, 2 and 3hr after carrageenan injection using digital plethysmometer. Results - Astraeus
hygrometricus showed significant anti-inflammatory activity at doses 200, 400 and 600 mg/kg compared to the
control group (p <0.05). On superoxide free radicals extracts showed radical scavenging at all concentrations, which
is lower than used standard ascorbic acid. The extract showed highest activity at concentration 250g/ml. Extracts
showed highest scavenging activity on H2O2 at 200g/ml concentration. Conclusions – The aqueous extract of
Astraeus hygrometricus has a good anti-inflammatory activity and considerable antioxidant potential.
Keywords: Astraeus hygrometricus, anti-inflammatory, carrageenan, antioxidant
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