EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

Impact Factor: 7.065

 ICV - 79.57

Abstract

IN VIVO EVALUATION OF ANTI-INFLAMMATORY AND ANTIOXIDANT POTENTIAL OF AQUEOUS EXTRACT OF ASTRAEUS HYGROMETRICUS ON ALBINO RATS

Sekhar Mandal, Shibani Basu, Tamoghna Maiti*, Ananya Mandal, Soumitra Mandal, Prasun Banerjee

ABSTRACT

Background and aims - Medicinal plants have been tested for their potential therapeutic effects. This study was designed to screen the in vivo anti-inflammatory activity of Astraeus hygrometricus in acute inflammation. Materials and methods – Anti-inflammatory activity was assessed by Carrageenan induced rat paw edema method. Albino rats of either sex were divided in 5 groups (N=6) [Group-I – saline control; Group- II, III and IV aqueous extracts of 200, 400, 600 mg/kg, P.O. respectively and Group- V Diclofenac1mg/kg, P.O. The paw volume was measured initially at 0, 1, 2 and 3hr after carrageenan injection using digital plethysmometer. Results - Astraeus hygrometricus showed significant anti-inflammatory activity at doses 200, 400 and 600 mg/kg compared to the control group (p <0.05). On superoxide free radicals extracts showed radical scavenging at all concentrations, which is lower than used standard ascorbic acid. The extract showed highest activity at concentration 250g/ml. Extracts showed highest scavenging activity on H2O2 at 200g/ml concentration. Conclusions – The aqueous extract of Astraeus hygrometricus has a good anti-inflammatory activity and considerable antioxidant potential.

Keywords: Astraeus hygrometricus, anti-inflammatory, carrageenan, antioxidant


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database Academia