EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

NEUTROPHIL TO LYMPHOCYTE RATIO VS PROCALCITONIN AS A MARKER FOR SEVERITY OF SEPSIS

Dr. Ankit P. Bhojani* and Dr. Yogitha C.

 

ABSTRACT

Background: Severe sepsis and septic shock, are the major cause of emergency room admission and are associated with high morbidity and mortality worldwide. Similarly mortality rate of sepsis in asia found to be 40%, so sepsis is still the leading cause of death. Delayed identification and inadequate resuscitation in severe sepsis and septic shock leads to the high mortality. We compared the accuracy of the neutrophil-lymphocyte count ratio (N/L) to conventional inflammatory markers in patients admitted to the Intensive Care Unit. Methods: The current study was a retrospective study performed in KIMS hospital Bangalore. The study cohort consisted of 50 patients admitted to the medicine ICU/MICU. Patients were admitted to the ICU when they had manifest or imminent organ failure, especially circulatory, respiratory or renal failure All patients age more than 18 admitted with sepsis were included in the study. In the current study, patients with a known or probable immune deficiency were excluded, including patients with a haematological disease, patients treated with chemotherapy or immunosuppressive therapy including glucocorticoids. Procalcitonin levels and all routine investigations including investigations to find out source of sepsis were documented.Neutrophil/lymphocyte ratio was calculated, APACHE score and PCT were documented.all these parameters were compared based on outcome of the patient. Results: Significant differences in N/L ratio values were observed between sepsis and non-sepsis patients (12.3 vs. 2.4 ; P<0.001) The area under the ROC curve of the NLCR was 0.78. AUROC was significantly higher for PCT 0.86. APACHE 2 score correlated well with procalcitonin levels and the N/L ratio was found to be higher in the sepsis group than the non sepsis group. Conclusion: In the very busy emergency room where calculating APACHE 2 score or other scoring systems for sepsis is time consuming and expensive,other less expensive and time saving markers need to be implemented one such marker is the Neutrophil to lymphocyte ratio which can be calculated to assess the severity of sepsis but prognosis does not correlates well with serum procalcitonin levels and APACHE 2 score.

Keywords: Sepsis, Septic shock, procalcitonin, neutrophil lymphocyte ratio.


[Full Text Article]

INDEXING

NEWS & UPDATION

  • New Issue Published

    Its Our pleasure to inform you that, EJPMR 1 December 2021 Issue has been Published, Kindly check it on http://www.ejpmr.com/home/current_issues

  • EJPMR: DECEMBER ISSUE PUBLISHED

    DECEMBER Issue has been successfully launched on 1 December 2021.

  • EJPMR New Impact Factor

    Its our Pleasure to Inform you that EJPMR Impact Factor has been increased from  5.804 to 6.222, due to high quality Publication at International Level

  • Index Copernicus Value

    EJPMR Received Index Copernicus Value 79.57, due to High Quality Publication in EJPMR at International Level

  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.

    .

  • Article Invited for Publication

    Article are invited for publication in EJPMR Coming Issue

Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )