FORMULATION AND EVALUATION OF SATRANIDAZOLE DENTAL STRIPS FOR USE IN PERIODONTITIS

K. Pragathi*, P. Prasuna Sundari, Dr. M. Bhagavan Raju

ABSTRACT

Periodontal strip is a dental device with very small loading dose for site specific one time continuous delivery of drug. Periodontitis is a of inflammatory disease affecting the tissues surrounding the teeth. Periodontitis involves progressive loss of the alveolar bone around the teeth, and if left untreated, can lead to the loosening and subsequent loss of teeth. This condition is treated using antibacterial agents by oral route. It has been observed that drug administration by this route caused adverse reactions due to high dose. The concept of delivering the drug directly into the periodontal pocket led to the development of local drug delivery systems. This concept gained attention as it requires low dose, produces sustained action and delivers the drug near to or onto the target site. The objective of present study is to formulate and evaluate satranidazole dental strips for use periodontitis. Dental strips were prepared by solvent casting method by using various polymers like, Ethyl cellulose, HPMC K4M, HPC, and Eudragit RL 100 in varying concentrations. The prepared formulations were evaluated for weight variation, thickness, content uniformity, invitro drug release studies. Stability studies were formulated with SF7 containing polymers Ethyl cellulose and HPMC K4M was considered as the best formulation based on invitro drug release of 96.43% in 7 days. The formulation found to be stable over a period of three months stability. Further work to done the antibacterial activity of the developed formulation will help to suggest that satranidazole dental strip provide an alternative for use in periodontitis.

Keywords: periodontitis, dental strip, satranidazole, sustain release.