DISSOLUTION ENHANCEMENT OF POORLY SOLUBLE AZITHROMYCIN USING SOLID DISPERSION METHOD
Sangram Sathe*, Datta Surwase, K.J. Kore, M.Y. Bagade, R.V. Shete.
Solid dispersion technique is used to improve solubility and dissolution. So the main purpose of this investigation was to increase the solubility and dissolution rate of Azithromycin is incorporated with water soluble carriers with PEG 6000, Poloxamer 407, PVP K30 using solvent evaporation method. Physical mixtures and solid dispersions of Azithromycin were prepared by using as water-soluble carrier in various proportions (1:1, 1:2, 1:4, 1:6, by weight), by employing solvent evaporation method. Dissolution studies showed satisfied drug release. The prepared formulations were evaluated for percentage yield, drug content studies The drug and the carrier compatibility study were determined with the help of IR spectroscopy.
Keywords: Solid dispersion, PEG 6000, Poloxamer 407,PVP K30, Azithromycin.
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