EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

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Abstract

METHOD DEVELOPMENT AND VALIDATION FOR ESTIMATION OF CLASS II SLOVENTS IN LULICONAZOLE BY HSGC-FID

*Mohd. Khaja Yaqub Ali, Dr. V. Murali Balaram, M. Mushraff Ali Khan and Dr. Anupama Koneru

 

ABSTRACT

Method Development and validating the HS-Gas chromatography was carried on DB-624, (30mx0.53mm) 3.0micron column, using quantified solvents and by modifying the temp. of oven, flow of carrier gas with Flame ionization detector. The process was linear at 25-150 μg /ml for solvents Methanol, Cyclohexane, Methyl isobutyl ketone and Toluene (r2>0.999). So, developed method shows good agreement with increased conc. Levels of Luliconazole. Recovery studies determined at 50%, 100% and 150% levels, it was inferred to be in acceptance limits 80% to 120%. Precision performed with 6 replicates using the solvents Methyl isobutyl ketone, Tolune, Cyclohexane, methanol using DMSO as diluent was inferred that the RSD% in limits. Recovery experiments indicated the absence of interference from commonly encountered diluent and API. The method was found to be precise as indicated by the repeatability analysis, showing %RSD less than 10 for Methanol, Cyclohexane, Methyl isobutyl ketone and Toluen. The method found to be within limits for detection and quantification limit.

Keywords: Luliconazole, HS-GC, FID Detectors, Residual solvents.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database Academia