EVALUATION OF ETHANOLIC EXTRACT OF ZIZYPHUS XYLOPYRUS WILLD ON WOUND HEALING ACTIVITY IN RATS

Rakesh K. Jain, Megha Tiwari, Vaibhav Rajoriya, Akash Sharma, Dr. Varsha Kashaw*

ABSTRACT

Ziziphus xylopyrus Willd. (Z. xylopyrus) is reported for widely use in diarrhoea, chest pain, analgesic, anti-inflammatory and healing of wounds in folk medicine. The in vivo wound healing activity of ethanol extract of Z. xylopyrus leaves was studied using excision and incision wound models in Swiss Albino rats. In order to achieve the aim, wound healing activity of ethanolic extract of Z. xylopyrus leaves were studied using excision and incision wound models in healthy Swiss Albino rats. The excision wound model was applied to measure breaking strength and hydroxyproline content and Incision wound model were applied to measure the bound area in mm. The extract administered topically at different dosages (50 mg/kg, 100 mg/kg and 200 mg/kilogram) per day for 10 days and evaluated for wound healing action. The wound healing potential of ethanolic extract of leaves at 200 mg/kg dose in both the model excision and incision was extremely significant and equivalent to standard. In the excision wound model, treated animals showed a significant reduction in the wound area, epithelization period and increase percent of wound contraction which was equivalent to standard. Results obtained from the present work, it can be inferred that the ethanolic extract of Z. xylopyrus leaves contributing to the stated activities. Further an exhaustive phytochemical work is needed in order to isolate, characterize and perform bioassays for the compound providing angiogenic as well as wound healing activity.

Keywords: Z. xylopyrus, Wound healing activity, wound healing potential.