EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

EVALUATION OF ETHANOLIC EXTRACT OF ZIZYPHUS XYLOPYRUS WILLD ON WOUND HEALING ACTIVITY IN RATS

Rakesh K. Jain, Megha Tiwari, Vaibhav Rajoriya, Akash Sharma, Dr. Varsha Kashaw*

ABSTRACT

Ziziphus xylopyrus Willd. (Z. xylopyrus) is reported for widely use in diarrhoea, chest pain, analgesic, anti-inflammatory and healing of wounds in folk medicine. The in vivo wound healing activity of ethanol extract of Z. xylopyrus leaves was studied using excision and incision wound models in Swiss Albino rats. In order to achieve the aim, wound healing activity of ethanolic extract of Z. xylopyrus leaves were studied using excision and incision wound models in healthy Swiss Albino rats. The excision wound model was applied to measure breaking strength and hydroxyproline content and Incision wound model were applied to measure the bound area in mm. The extract administered topically at different dosages (50 mg/kg, 100 mg/kg and 200 mg/kilogram) per day for 10 days and evaluated for wound healing action. The wound healing potential of ethanolic extract of leaves at 200 mg/kg dose in both the model excision and incision was extremely significant and equivalent to standard. In the excision wound model, treated animals showed a significant reduction in the wound area, epithelization period and increase percent of wound contraction which was equivalent to standard. Results obtained from the present work, it can be inferred that the ethanolic extract of Z. xylopyrus leaves contributing to the stated activities. Further an exhaustive phytochemical work is needed in order to isolate, characterize and perform bioassays for the compound providing angiogenic as well as wound healing activity.

Keywords: Z. xylopyrus, Wound healing activity, wound healing potential.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )