EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

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Abstract

EFFECTS OF PREDATOR INDUCED PSYCHOSOCIAL STRESS ON SPERM PARAMETERS OF ALBINO WISTAR RATS

Uwejigho R., Olotu E. J., Osunwoke E. A. and Aigbogun (Jr), E. O.*

 

ABSTRACT

Aim and objectives: This study evaluated the durational effects of predator-induced psychosocial stress on the sperm parameters using animal models. Materials and Methods: The rats were divided into four (4) equal groups (n=5). Groups A to B (short duration for 52 days) and groups C to D (long duration for 104 days). Groups A and C served as the controls, which were not stressed, while Group B and D were psychosocially stressed in the PTSD chamber at 3hr/exposure daily for 52 and 104 days respectively. The animals from Group A/B and C/D were sacrificed on the 53rd and 105th day respectively, and their total sperm count (×106 cells/ml), abnormal morphology (%), motility (%), immotility (%), progressive (%), and non-progressive (%) sperm determined. GraphPad Prism Version 8 (San Diego, USA) was used to analyse the data and the results described as mean ± Standard Error of Means (S.E.M.). Unpaired t-test (at 95% confidence level) was used to compare values of the control and experimental groups. Results: The result showed that the mean(S.E) sperm count (×106) for control A (39.00±3.32 cells/ml) and B (40.00±3.16 cells/ml) were significantly greater than their experimental groups (52 days [17.00±1.23 cells/ml] and 104 days [18.05±1.23 cells/ml]) respectively (P<0.001). On the other hand, the abnormal, immotile, and non-progressive sperm cells were significantly greater (P<0.01) in the experimental groups when compared to their respective controls; with better sperm parameters observed at day 104 when compared to day 52. Conclusion: The initial exposure of animals to chronic stress for 52 days was deleterious to sperm parameters; however, further exposure (twice the initial duration) produced results that suggested a kind of coping mechanism that reduced the damages.

Keywords: Sperm parameters, Chronic stress, Psychosocial stress, Animal model.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )