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An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

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 ISSN 2394-3211

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Epa C.*, Moulari B., Okiemy Akeli M. G., Ampa R., Etou Ossibi A. W., Moudilou O. C. P., Agbonon Amegnona, Attibayeba, Ongoka P. R. and Abena A. A.



Maranthes glabra known under the vernacular name "Yandza teke" is a medicinal plant of the family Chrysobalanaceae, widely used in traditional medicine in Congo. In the present work, three extracts have been prepared from the bark of this plant: ethanolic, hydroethanolic and aqueous extracts. The aqueous extract was administered to normoglycemic albino wistar rats, in temporary hyperglycemia after glucose overload and made diabetic by administration to the penis dorsal vein of streptozotocin at 50 mg / kg body weight. The results showed that after 2 hours, basal blood glucose levels in normal rats significantly increased from 0.86 ± 0.05 to 0.75 ± 0.05 g / L at 500 mg / kg of aqueous extract, and from the third hour, aqueous extract at 200 mg / kg induces a significant blood glucose level decrease (P <0.05). The oral glucose tolerance test showed hyperglycemia in rats one hour later. This hyperglycemia was expressed mainly in the control rats that received distilled water, compared to rats treated with glibenclamide and at different extract concentrations. The aqueous extract of Maranthes glabra therefore has the ability to protect animals against hyperglycemia. Glycemic monitoring of diabetic rats revealed that there was a significant (P <0.05) and / or more marked (P <0.01) reduction in blood glucose up to the third hour for both extract concentrations (200 and 500mg / kg). The antioxidant evaluation by the DPPH method indicated that the ethanolic extract had a good antioxidant efficiency exceeding (IC50 = 0.195 ± 0.001 mg / ml) that of gallic acid (IC50 = 0.234 ± 0.000 mg / ml) because of the lower concentration. The chemical screening of bark made by standard colorimetric reactions has shown the richness of these in different chemical families. And the quantitative evaluation of polyphenols and total flavonoids by the colorimetric method showed that the three types of extracts are rich in these phenolics.

Keywords: Maranthes glabra extracts, antioxidant activity, antidiabetic activity.

[Full Text Article]



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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )