FORMULATION AND EVALUATION OF CONTROLLED-RELEASE OF BENAZEPRIL MICROSPHERES

Ravi K. V., Dr. Vinay C. H.*, N. Suresh, Mahaveer Singh and Nagesh C.

ABSTRACT

Microspheres of Benazepril HCl were prepared using Chitosan and Xanthan gum by solvent evaporation technique. Compatibility study was carried out by using FTIR and results showed that there was no significant interaction between drug and excipients. Microspheres thus obtained were found to be pale yellow in color and showed free flowing character. The Scanning electron microscopy results indicate that microspheres are of smooth and spherical in shape. Particle size was performed by using optical microscope and particle sizes are found in the range 152.8±8.35 to 276.2±5.47μm and particle size depends up on the concentration of Xanthan gum i.e. formulation containing higher concentration of Xanthan are larger size when compared to Chitosan containing batches. Entrapment efficiency results showed that formulation F10 containing 1:9 ratio of Chitosan: Xanthan gum showed highest percentage of entrapment (95.90%) and showed 59.74% of drug loading. Dissolution studies showed decreases as concentration of Xanthan gum increases the dissolution profile of Benazepril HCl from prepared formulation. Formulation F2 containing 9:1 ratio of Chitosan: Xanthan gum showed 94.86% of drug release at the end of 12 hours. Short term stability study showed that prepared Benazepril microsphere formulation was physicochemically stable throughout stability period. Hence it was conclude that, microspheres offer a practical and suitable approach to prepare controlled release dosage form of Benazepril HCl with natural gums like Chitosan and Xanthan gum.

Keywords: Benazepril HCl; Chitosan; Xanthan gum; microspheres; Solvent evaporation.