EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

Impact Factor: 7.065

 ICV - 79.57

Abstract

FORMULATION AND EVALUATION OF CONTROLLED-RELEASE OF BENAZEPRIL MICROSPHERES

Ravi K. V., Dr. Vinay C. H.*, N. Suresh, Mahaveer Singh and Nagesh C.

 

ABSTRACT

Microspheres of Benazepril HCl were prepared using Chitosan and Xanthan gum by solvent evaporation technique. Compatibility study was carried out by using FTIR and results showed that there was no significant interaction between drug and excipients. Microspheres thus obtained were found to be pale yellow in color and showed free flowing character. The Scanning electron microscopy results indicate that microspheres are of smooth and spherical in shape. Particle size was performed by using optical microscope and particle sizes are found in the range 152.8±8.35 to 276.2±5.47μm and particle size depends up on the concentration of Xanthan gum i.e. formulation containing higher concentration of Xanthan are larger size when compared to Chitosan containing batches. Entrapment efficiency results showed that formulation F10 containing 1:9 ratio of Chitosan: Xanthan gum showed highest percentage of entrapment (95.90%) and showed 59.74% of drug loading. Dissolution studies showed decreases as concentration of Xanthan gum increases the dissolution profile of Benazepril HCl from prepared formulation. Formulation F2 containing 9:1 ratio of Chitosan: Xanthan gum showed 94.86% of drug release at the end of 12 hours. Short term stability study showed that prepared Benazepril microsphere formulation was physicochemically stable throughout stability period. Hence it was conclude that, microspheres offer a practical and suitable approach to prepare controlled release dosage form of Benazepril HCl with natural gums like Chitosan and Xanthan gum.

Keywords: Benazepril HCl; Chitosan; Xanthan gum; microspheres; Solvent evaporation.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database Academia