EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

Impact Factor: 7.065

 ICV - 79.57

Abstract

EVALUATION OF THE EFFECT OF AQUEOUS LEAF EXTRACT OF JUTE MALLOW Corchorus olitorius ON SOME BIOCHEMICAL PARAMETERS IN ALLOXAN-INDUCED DIABETIC RATS

A. Mohammed*, C. D. Luka, A. L. Ngwen, O. F. R. Omale and B. J. Yaknan

 

ABSTRACT

Plants form the main ingredients of medicine in traditional system of healing and have been the source of inspiration for several major pharmaceutical drugs. The study was carried out to investigate the effect of the aqueous leaf extract of Jute Mallow (Corchorus olitorius) on Serum blood glucose, protein, albumin, total bilirubin, direct bilirubin, total cholesterol, triglyceride, high density lipoprotein (HDL), low density lipoprotein (LDL) and enzymes activities on normal and alloxan-induced diabetic rats. The aqueous leaf extract was administered orally at a dose of 400mg/kg body weight to both normal and alloxan-induced diabetic rats. Twenty adult male rats were divided into four groups of five rats each, two groups were made diabetic and the other two groups were non-diabetic. One of the diabetic groups was treated with the leaf extract and the second serves as diabetic control. The alloxan was administered intraperitoneal at a dose of 150mg/kg per body weight. The administration of the leaf extract lasted for 28 days. Effect of the extract on blood glucose, protein, albumin, total bilirubin, direct bilirubin total cholesterol; triglyceride, high density lipoprotein and low density lipoprotein concentrations were analyzed. The toxic effect of the leaf extract was determined using biochemical enzyme markers. The photochemical screening of the ethanol extract showed the presences of Alkaloid, Tannins, Resins, Terpenes and steroids, Balsam, Carbohydrate and Phenol, while aqueous extract showed the presences of Alkaloid, Tannins and Resins and chloroform extracts showed the presences of Alkaloid only. Treatment with the extract showed significant (P<0.05) reduction on the serum blood glucose level and other biochemical parameters analyzed. The extract possesses no toxic effect as indicated by the lowering of ALP and ALT levels and may be used for the management of diabetes mellitus.

Keywords: Corchorus olitorius, phytochemical, lipid profile, liver enzymes, hypolipidaemic.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database Academia