( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Scope Database , Academia , 

 ISSN 2394-3211

Impact Factor: 7.065

 ICV - 79.57



Ranjit Kumar*, Md. Ali, Arun Kumar and Vibha Gahlot


Since last two decades, the phyto-remediation for pesticide borne diseases has remained a matter of great challenge. Pesticides are commonly used for protection of crops from different pests. Now a day’s organophosphates are commonly used pesticide. Some of the pesticides persist in the environment and also bio-accumulate into different organisms. The present work is designed to study the bioremedial effect of Withania somnifera (Ashwagandha) and Curcuma longa (Turmeric) on ovaries of Chlorpyrifos exposed Swiss albino mice. The end point of bioremedial effect is measured by restoration of estrogen and cholesterol levels. The treatment groups received Chlorpyrifos at 6mg/kg b.w./day by Gavage method for eight weeks followed by eight weeks administration of alcoholic root extract of Withania somnifera and rhizome extract of Curcuma longa separately at the dose of 50mg/kg b.w./day. Chlorpyrifos administered groups showed increased level of Estrogen and Cholesterol. Withania and Curcuma treated groups showed restoration in Estrogen and Cholesterol levels. Restoration of Cholesterol level is more in Withania treated group while Curcuma treated group restores Estrogen level significantly. Ovaries of Chlorpyrifos administered groups showed degenerated germinal epithelium, Graafian follicles and corpus luteum. Withania treated group showed more restoration in germinal epithelium, Graafian follicles and corpus luteum than Curcuma treated group comparatively. Thus it is evident from the study that Withania somnifera plays effective role against Chlorpyrifos induced toxicity on biochemical, hormonal and histology of ovary in comparison to Curcuma longa.

Keywords: Chlorpyrifos, Graafian follicle, Estrogen, Cholesterol.

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  • New Issue Published

    Its Our pleasure to inform you that, EJPMR 1 May 2024 Issue has been Published, Kindly check it on


    MAY 2024 issue has been successfully launched on MAY 2024.

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    EJPMR Impact Factor has been Increased to 7.065 for Year 2024.

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database Academia