SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL EVALUATION OF SOME NOVEL OXADIAZOLE DERIVATIVES FROM PHTHALIMIDE MOIETY
Oxadiazole ring has two carbon, two nitrogen and one oxygen atom. There are four types of oxadiazole rings such as 1,2,3-oxadiazole 1,2,4-oxadiazole, 1,3,4-oxadiazole and 1,3,5-oxadiazole. While 1, 3, 4-oxadiazole has been known for about 80 yrs. it is first and foremost chemical molecule due to its highest useful characteristic in different areas. The further name of 1,3,4-oxadiazoles are furo diazole, biazole, oxybiazole. The 1, 3, 4-oxadiazole derivatives have been found to exhibit diverse biological activities such as anti-inflammatory, analgesic, anti-fungal and antibacterial activities. Apart from that it is also important for tuberculosis, cancer, HIV infection, low glucose levels and many other pathological conditions. In this research work we have synthesized and evaluated a number of derivatives having an oxadiazole moiety. Oxadiazole has an important role for this determination and this moiety may serve as new pattern for the synthesis of safer & prospective antimicrobial agents. In view of the broad spectrum of important biological activities including anti-inflammatory, antibacterial, antifungal and analgesics etc of oxadiazole derivatives, it has been well thought-out useful to work on this system i.e. oxadiazole skeleton. Oxadiazole derivative is synthesized by using the 3-nitro-phthalimide. The structures of the newly synthesized compounds have been established on the basis of spectral analytical data such as IR, 1H-NMR, Mass and elemental analysis. 4-nitro-2-((5-propyl-1,3,4-oxadiazol-2-yl)methyl)isoindoline-1,3-dione shows broad spectrum activities of antibacterial and antifungal. All the synthesized compounds are evaluated for anti-bacterial activity by disc diffusion technique. The minimum inhibitory concentrations (MIC) are determined by using the twofold serial dilution technique.
Keywords: Oxadiazole derivatives, Antibacterial and Antifungal.
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