( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Scope Database , Academia , 

 ISSN 2394-3211

Impact Factor: 7.065

 ICV - 79.57



Nidhi Dhama*


Oxadiazole ring has two carbon, two nitrogen and one oxygen atom. There are four types of oxadiazole rings such as 1,2,3-oxadiazole 1,2,4-oxadiazole, 1,3,4-oxadiazole and 1,3,5-oxadiazole. While 1, 3, 4-oxadiazole has been known for about 80 yrs. it is first and foremost chemical molecule due to its highest useful characteristic in different areas. The further name of 1,3,4-oxadiazoles are furo diazole, biazole, oxybiazole. The 1, 3, 4-oxadiazole derivatives have been found to exhibit diverse biological activities such as anti-inflammatory, analgesic, anti-fungal and antibacterial activities. Apart from that it is also important for tuberculosis, cancer, HIV infection, low glucose levels and many other pathological conditions. In this research work we have synthesized and evaluated a number of derivatives having an oxadiazole moiety. Oxadiazole has an important role for this determination and this moiety may serve as new pattern for the synthesis of safer & prospective antimicrobial agents. In view of the broad spectrum of important biological activities including anti-inflammatory, antibacterial, antifungal and analgesics etc of oxadiazole derivatives, it has been well thought-out useful to work on this system i.e. oxadiazole skeleton. Oxadiazole derivative is synthesized by using the 3-nitro-phthalimide. The structures of the newly synthesized compounds have been established on the basis of spectral analytical data such as IR, 1H-NMR, Mass and elemental analysis. 4-nitro-2-((5-propyl-1,3,4-oxadiazol-2-yl)methyl)isoindoline-1,3-dione shows broad spectrum activities of antibacterial and antifungal. All the synthesized compounds are evaluated for anti-bacterial activity by disc diffusion technique. The minimum inhibitory concentrations (MIC) are determined by using the twofold serial dilution technique.

Keywords: Oxadiazole derivatives, Antibacterial and Antifungal.

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database Academia