FORMULATION AND EVALUATION OF FAST DISSOLVING ORAL FILMS CONTAINING ETORICOXIB USING NATURAL SUPER DISINTEGRANTS

Muhamed Rizvan Ebrahimkutty*, Shripathy D. and Dr. A. R. Shabaraya

ABSTRACT

The present investigation was under taken with the objective of formulating fast dissolving oral films containing Etoricoxib using natural super disintegrant to enhance the convenience and compliance by the elderly and pediatric patients. Etoricoxib is a Non-steroidal anti-inflammatory drug (NSAID) belonging to COX II inhibitor class of drug. The oral films of etoricoxib was prepared by solvent casting method using Xanthan gum and Guar gum as a film forming agents, Plantago ovate as natural super disintegrating agent and PEG 400 as plasticizer. Nine formulations were prepared and were evaluated for physico-mechanical properties, in-vitro disintegration time and in-vitro dissolution studies. All formulated films showed the good physico-mechanical properties, in-vitro disintegration time. The formulation F3 showed better dissolution of 96.6% at the end of 14 minutes.

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