EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Scope Database , Academia , 

 ISSN 2394-3211

Impact Factor: 7.065

 ICV - 79.57

Abstract

A COMPARITIVE EFFICACY STUDY OF METFORMIN AND INSULIN ON NEONATAL OUTCOMES AMONG GESTATIONAL DIABETES MELLITUS PATIENTS

Akhila T. S., Anand A. S.*, Liya Kuriakose, Shabina M. and NIthin Manohar R.

ABSTRACT

Background: To compare the efficacy of Metformin and Human Insulin on neonatal outcomes in gestational diabetes mellitus patients. Methods: A total of 120 patients with GDM were selected in which 60 patients with metformin and 60 patients with insulin. Neonatal outcomes such as Gestational age, birth weight, APGAR score, Hypoglycemia, Hyperbilirubinemia and respiratory distress were collected at the time of birth. Result: It was found that metformin is comparable with insulin and can be used as an alternative to insulin. Effectiveness via glucose control was almost same for both groups. Preterm delivery was significantly higher in insulin group than in metformin group. Regarding neonatal outcomes, neonatal hyperbilirubinemia was significantly lower in metformin treated group. All other neonatal outcomes (body weight, neonatal hypoglycaemia, neonatal respiratory distress) and mode of delivery were comparable. Conclusion: Metformin is found to be as effective as Insulin in the treatment of Gestational Diabetes Mellitus.Compared to Insulin, Metformin is a safer, cheap and convenient first line drug of choice for Gestational Diabetes Mellitus.

Keywords: Gestational diabetes mellitus, insulin, metformin, OGTT.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database Academia