EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

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Abstract

METHOD DEVELOPMENT AND VALIDATION FOR SIMULTANEOUS ESTIMATION OF PANTOPRAZOLE, DICLOFENAC & CHLORZOXAZONE BY RP-HPLC METHOD

Geddada Bhavana*, Dr. Devanaboyina Narendra, Gadi Vijaya Lakshmi and Rajanala Rajeswari

ABSTRACT

A simple, accurate, precise method was developed for the simultaneous estimation of the Chlorzoxazone (CLZ), Pantoprazole (PTP) and Diclofenac (DCF) in solid dosage form. Chromatogram was run through Discovery C18 150x4.6mm, 5. Mobile phase containing Buffer and Acetonitrile in the ratio of 42:58 v/v was pumped through column at a flow rate of 0.75ml/min. Buffer used in this method was 0.1% Orthophosphoric acid (OPA). Temperature was maintained at 30°C. Optimized wavelength for Chlorzoxazone. Pantoprazole and Diclofenac was 229.0 nm. Retention time of Chlorzoxazone, Pantoprazole and Diclofenac were found to be 2.233min, 2.763min and 3.759min %RSD of system precision for Chlorzoxazone, Pantoprazole and Diclofenac. were and found to be 1.0, 0.9and 0.6 respectively. %RSD of method precision for Chlorzoxazone, Pantoprazole and Diclofenac.were and found to be 0.6, 0.2 and 0.3 respectively. % recovery was Obtained as 99.88%, 99.81% and 99.75% for Chlorzoxazone, Pantoprazole and Diclofenac. respectively. LOD, LOQ values are obtained from regression equations of Chlorzoxazone, Pantoprazole and Diclofenac. were 0.14ppm, 0.22ppm, 2.88ppm and 0.42pm, 0.67ppm ,8.72 ppm respectively. Regression equation of Chlorzoxazone.wasy= 6226.1x + 745.53, Pantoprazole was y = 17987x + 3754.7. and of Diclofenac was y = 10072x + 32901.

Keywords: Chlorzoxazone, Pantoprazole, Diclofenac, RP-HPLC.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database Academia