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An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Scope Database , Academia , 

 ISSN 2394-3211

Impact Factor: 7.065

 ICV - 79.57



Jograna M.B.*, Bhosale A.V. and Kakade S.S.


Amlodipine (3-ethyl-5-methyl-2-(2-aminoethoxymethyl)-4-(2-chlorophenyl)-1, 4-dihydro-6-methyl-3,5-pyridinedicarboxylate) is used to treat high blood pressure and chest pain (angina). Amlodipine is given orally (5mg or 10mg daily) with peak plasma concentration occurring after 6-12 hrs, and has oral bioavailability of 60-65% only due to extensive hepatic metabolism. Amlodipine belonging to the 1, 4-dihydropyridine class are photosensitive since light catalyzes their oxidation to pyridine derivatives, lacking any therapeutic effect. From a pharmaceutical point of view, dry emulsions are attractive because they are physically and microbiologically stable formulations, which are easy to administer in the form of powders as capsules and tablets. Hence a novel a solid form of lipid-based self- emulsifying drug delivery system (SEDDS) is formulated by spray drying liquid SEDDS with an inert solid carrier to improve the photostability and oral bioavailability of poorly water-soluble drug amlodipine. Solid self-emulsifying drug delivery systems of amlodipine were prepared by using different oils, surfactants and co-surfactants and evaluated for its in vitro performance. Optimized, Solid amlodipine SEDD composed of amlodipine (5 mg), Labrafil M1944 CS (30%), Smix (70%) and Maltodextrin (10 gm). The globule size distribution of this formulation was within appropriate range (0.600–0.900 μm). In vitro release in 0.1 N HCl revealed a prompt release within 5 minute up to 90%. SEDDS of amlodipine showed a significant increase in photostability and oral bioavaibility of amlodipine.

Keywords: Amlodipine, Solid self-emulsifying drug delivery system (SEDDS), Bioavailability, Photostability.

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database Academia