EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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ISSN 2394-3211

Impact Factor: 7.065

ICV - 79.57

Abstract

CARDIOPROTECTIVE AND ANTIOXIDANT POTENTIAL OF 50% HYDROETHANOLIC CRUDE EXTRACT OF THEOBROMA COCOA IN ISOPROTERENOL – INDUCED MYOCARDIAL RATS

Ragavan Balliah*, Suganya, Monisha Sudhakar

ABSTRACT

Theobroma Cocoa is an important export product of many developing countries for production of cocoa powder and chocolate. Therefore, the present study aimed to evaluate the cardioprotective effect of Theobroma Cocoa on isoproterenol induced myocardial in rat. The experimental albino rats were divided into four groups. The 50% hydroethanolic extract of Theobroma Cocoa was orally administered to group 3 and 4 rats for 28 days. Isoproterenol (20mg/100g) subcutaneously injected twice at an interval of 24 hr to group 3 rats on 29 and 30th day. At the end, rats were scarified and collected serum and heart samples for biochemical and histopathological studies. Significant (P<0.05) results were observed on protein, urea ,uric acid, and creatinine, serum lipid profile, cardiac marker enzymes and antioxidants in group 3 rats nearer to normal. The Histopathological observation showed the cardioprotective action of the study plant.

Keywords: Theobroma Cocoa, Isoproterenol, Marker enzymes, Myocardial Infarction, Cardioprotective, Lipid profile.

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