EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

A REVIEW ON CONTROLLED RELEASE FLOATING DRUG DELIVERY SYSTEMS IN PHARMACEUTICAL FORMULATIONS

Dr. Sarad Pawar Naik B.*, Yasoda K., Soundarya M., Govardhini G., T. M. Hemanath and S. Rithesh Krishna

ABSTRACT

Over the years there has been available a variety of drug modification and dosage forms, with which we have attempted to control the time course and specificity of drugs in the body maximize drug utilization, it is necessary to deliver the drug to its target tissue in the correct amount at the proper time to elicit the desired response. The most convenient method of controlled delivery of drug is undoubtedly oral, but oral controlled release of the drug for an extended period of time that exhibits more absorption in stomach and upper small intestine, has not been successful with conventional approaches. Consequently, most research efforts have been focused on platforms to extend gastric residence time (GRT) of these drugs. The novel design of Oral Controlled Drug Delivery System (OCDDS) should be primarily aimed at achieving a more predictable and increased bioavailability of drugs. However, the development process is precluded by several physiological difficulties, such as inability to restrain and localize controlled drug delivery systems (CDDS) within the desired regions of the gastrointestinal (GI) tract and highly variable nature of the gastric emptying process. Thus, conventional OCDDS has not been suitable for a variety of important drugs which has any of above mentioned characteristics, which is mainly due to the relatively short transit time of the dosage form in the stomach and upper part of small intestine. The overall results are accompanied by lesser bioavailability. Furthermore, the relatively brief gastric emptying time in humans, which normally range from 2 - 3 hours through the major absorption zone (stomach or upper part of intestine), can result in incomplete drug release from the dosage form leading to diminished efficacy of the administered dose. Thus, control of placement of drug delivery system in a specific region of the GI tract offers numerous advantages. From the formulation and technological point of view, the Floating Drug Delivery System (FDDS) is considerably an easy and logical approach in the development of gastro retentive dosage forms. Hence in the present study, the formulation of Gastro Retentive Dosage Forms (GRDFs) is done by FDDS.

Keywords: Floating Drug Delivery System (FDDS), Controlled Drug Delivery Systems (CDDS), Gastro Retentive Dosage Forms (GRDFs) and Gastrointestinal (GI) tract.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )