EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

Impact Factor: 7.065

 ICV - 79.57

Abstract

VERAPAMIL - HYDROCHLORIDE AT LOW CONCENTRATIONS INHIBITS THE GROWTH OF RELAPSE GLIOBLASTOMA

N. Ya. Gridina* A. N. Morozov, V. D. Rozumenko, A. A. Shmeleva and Yu. V. Ushenin

ABSTRACT

The life expectancy of glioblastoma patients was investigated in the distant postoperative period. These patients were treated with such concentrations of verapamil – hydrochloride, that minimize the level of blood cells aggregation in II stage of the inflammatory process. 11 patients received treatment (I group) and 32 patients did not received treatment (II group) with calcium blocker using verapamil – hydrochloride examples in pills. For the objectification of tumor association inflammation (TAI), that present’s in the patient’s body, the definition of blood cells aggregation was examined on the “Plasmon” sensor. Peripheral blood cells were collected from patients to determine the indicators of blood cells aggregation with the addition of various aqueous of verapamil – hydrochloride (from 1: 10 to 1: 100,000 times). Patients took drugs at the lowest level of blood cells aggregation doses. Drug dose was performed by decreasing its concentration by a factor of 10, 000. From the 43 patients, admitted to the clinic, only 3 patients did not undergo chemotherapy at will. After the surgical removal of glioblastoma and the postoperative irradiation course, they only took verapamil – hydrochloride at low concentration daily. In the I group of 8 patients, undergoing combined treatment courses and taking verapamil - hydrochloride, the average life expectancy was 18.6 ± 1.82 months and 8.47 ± 1.02 months in the group of 32 patients (Cox’s F - test p = 0,00108). Three patients without chemotherapy in the postoperative period received daily treatment with verapamil – hydrochloride without interruption for life. All 3 patients continue to live for 19, 25 and 29 months, respectively. The paper presents for the first time the results of highly malignant glioblastoma treatment with low concentrations of the NMDA-dependent calcium blocker verapamil – hydrochloride. The results indicate a high antitumor activity of the drug, both when used together with traditional methods of treatment or separately.

Keywords: Glioblastoma, tumor-associated inflammation, verapamil-hydrochloride, low concentrations, life expectancy.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database Academia