EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

NEW KNOWLEDGE ON PATHOGENESIS OF TOXIN PERFRINGENS LARGE (TPEL) FOR PRODUCTION OF NEW GENERATION VACCINE AND MOLECULAR WORKING, A REVIEW

Lida Abdolmohammadi Khiav, Reza Pilehchian Langroodi* and Alireza Paradise

ABSTRACT

Clostridium perfringens (C. perfringens) is an anaerobic and gram-positive, spore-forming bacterium. Clostridial infections are cause of the most important diseases including lamb dysentery, pulpy kidney, black disease, malignant oedema, and blackleg, with heavy losses over many years in Iran. Major and minor toxins have an important role in pathogenesis. The species is classified into five types (types A-E) based on the major toxin. A novel toxin (toxin perfringens large) (TpeL) has recently been identified from C. perfringens types A, B and C. This toxin belongs to large glycosylating toxins family which is cause of cytotoxic effects in Vero cells (including enlargement and the rounding of Vero cells). TpeL toxin is involved in the pathogenesis of avian enteric necrosis (including ostrich and chicken flocks) which can lead to the morbidity and mortality rate; therefore TpeL is considered as a virulence factor. This paper reviews the studies on molecular working (PCR) for detection of disease, determination of the biotypes of C. perfringens, analyze for genetic diversity using PFGE, immunoinformatics analysis and production of the new generation vaccine was performed on TpeL toxin. Finally, the new generation vaccine was evaluated the amount of antibody using serum neutralization assay in laboratory animals. The results of this study showed that the chimeric vaccine could be used as an effective vaccine against domestic animals disease. It is suggested that more research should be done on isolation, characterization, and purification. Furthermore, the evaluation of immunity could be performed in target animals.

Keywords: Clostridium perfringens, new generation vaccine, TpeL toxin.


[Full Text Article]

INDEXING

NEWS & UPDATION

  • New Issue Published

    Its Our pleasure to inform you that, EJPMR 1 November 2021 Issue has been Published, Kindly check it on http://www.ejpmr.com/home/current_issues

  • EJPMR: NOVEMBER ISSUE PUBLISHED

    NOVEMBER Issue has been successfully launched on 1 November 2021.

  • EJPMR New Impact Factor

    Its our Pleasure to Inform you that EJPMR Impact Factor has been increased from  5.804 to 6.222, due to high quality Publication at International Level

  • Index Copernicus Value

    EJPMR Received Index Copernicus Value 79.57, due to High Quality Publication in EJPMR at International Level

  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.

    .

  • Article Invited for Publication

    Article are invited for publication in EJPMR Coming Issue

Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )