EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

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 ICV - 79.57

Abstract

ANALYTICAL METHOD DEVELOPMENT AND VALIDATION OF CHLORPHENIRAMINE AND LEVODROPROPIZINE IN PURE AND DOSAGE FORM BY RP HPLC METHOD

K. Sruthi* and D. Dhachinamoorthi

ABSTRACT

A simple, Accurate, precise method was developed for the simultaneous estimation of the Chlorpheniramine and Levodropropizine in syrup dosage form. Chromatogram was run through Zodiasil C18 150 x 4.6 mm, 5. Mobile phase containing Buffer 0.01N Kh2po4: Acetonitrile taken in the ratio 65:35 was pumped through column at a flow rate of 1.0 ml/min.Optimized wavelength selected was 252 nm. Retention time of Chlorpheniramine and Levodropropizine were found to be 2.321 min and 2.948 min. %RSD of the Chlorpheniramine and Levodropropizine were and found to be 0.8 and 1.0 respectively. %Recovery was obtained as 99.59% and 99.29% for Chlorpheniramine and Levodropropizine respectively. LOD, LOQ values obtained from regression equations of Chlorpheniramine and Levodropropizine were 0.08, 0.23 and 0.48, 1.46 respectively. Regression equation of Chlorpheniramine is y = 13761x + 395.2. And y = 21327x +3227 of Levodropropizine. Retention times were decreased and run time was decreased, so the method developed was simple and economical that can be adopted in regular Quality control test in Industries.

Keywords: Chlorpheniramine, Levodropropizine, RP-HPLC.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database Academia