EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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ISSN 2394-3211

Impact Factor: 7.065

ICV - 79.57

Abstract

ANALYTICAL METHOD DEVELOPMENT AND VALIDATION OF CHLORPHENIRAMINE AND LEVODROPROPIZINE IN PURE AND DOSAGE FORM BY RP HPLC METHOD

K. Sruthi* and D. Dhachinamoorthi

ABSTRACT

A simple, Accurate, precise method was developed for the simultaneous estimation of the Chlorpheniramine and Levodropropizine in syrup dosage form. Chromatogram was run through Zodiasil C18 150 x 4.6 mm, 5. Mobile phase containing Buffer 0.01N Kh2po4: Acetonitrile taken in the ratio 65:35 was pumped through column at a flow rate of 1.0 ml/min.Optimized wavelength selected was 252 nm. Retention time of Chlorpheniramine and Levodropropizine were found to be 2.321 min and 2.948 min. %RSD of the Chlorpheniramine and Levodropropizine were and found to be 0.8 and 1.0 respectively. %Recovery was obtained as 99.59% and 99.29% for Chlorpheniramine and Levodropropizine respectively. LOD, LOQ values obtained from regression equations of Chlorpheniramine and Levodropropizine were 0.08, 0.23 and 0.48, 1.46 respectively. Regression equation of Chlorpheniramine is y = 13761x + 395.2. And y = 21327x +3227 of Levodropropizine. Retention times were decreased and run time was decreased, so the method developed was simple and economical that can be adopted in regular Quality control test in Industries.

Keywords: Chlorpheniramine, Levodropropizine, RP-HPLC.

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