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An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Scope Database , Academia , 

 ISSN 2394-3211

Impact Factor: 7.065

 ICV - 79.57



Gnaléi Rabé Marcellin*, Bahi Calixte, GUI Prisca Angèle, Tiekpa Wawa Justine and Coulibaly Adama


Diabetes mellitus is accompanied by oxidative stress and free radical production by various mechanisms. This oxidative stress is involved in the aggravation of the disease as well as in the occurrence of chronic complications related to diabetes. The objective of the present work is to study the antioxidant activity of the total aqueous extract of Phyllanthus muellerianus in diabetic rats. Diabetes is induced by a single daily dose of 10 mg / kg bw streptozotocin (STZ) for twenty-one (21) days. The animals were then treated for seven (7) days with a dose of different concentrations of the total aqueous extract (ETAq) of Phyllanthus muellerianus leaves (100, 200 and 300 mg / kg bw) and Glucidoral® (Glu) (10 and 20 mg / kg bw), a standard antidiabetic agent. After treatment, these rats were sacrificed, the liver was removed for the determination of superoxide dismutase and catalase activities, and the concentration of malondialdehyde. The induction of diabetes decreased the activities of superoxide dismutase and catalase, and increased blood glucose and malondialdehyde concentration in the liver of diabetic rats. In contrast, treatment with the aqueous total extract (ETAq) of Phyllanthus muellerianus and Glucidoral® (Glu) increased the activities of superoxide dismutase and catalase, and decreased blood glucose and concentration of malondialdehyde in the liver of these animals. The results showed that the total aqueous extract (ETAq) of Phyllanthus muellerianus leaves can protect cells from the oxidative stress that accompanies diabetes.

Keywords: Phyllanthus muellerianus, antioxidant activity, glucidoral, diabetic rats.

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database Academia