EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

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Abstract

SOME HEMATOLOGICAL PARAMETERS OF WISTAR RATS ADMINISTERED ETHANOLIC LEAF EXTRACT OF SPONDIAS MOMBIN DURING PREGNANCY

Njoku-Oji N. N.*, Ifegwu N. O., Umahi G. O., Maduka S. O., Uchefuna R. C., Enemuo I. C.,
Okonudo P. O. and Dibia C. L.

ABSTRACT

Background: The World Health Organization (WHO) estimates that anemia affects over half of the pregnant women in developing countries. In Eastern Nigeria, fresh leaves of S. mombin are used during and after parturition. Aim: To determine the effect of administration of ethanolic leaf extract of Spondias mombin on some hematological parameters of wistar rats during pregnancy. Materials and Methods: Twenty-eight (28) non-pregnant adult female rats weighing between 140-200g were used for this study. On confirmation of pregnancy, the animals were grouped into four groups of 7 rats each as follows: Groups I, II, III and IV. Administration of extract began on the first day of the second trimester (day 4) and terminated on the sixth day of third trimester (day 20). The ethanolic leaf extract was administered daily via oral gavage at 100, 200 and 400mg/kg body weight to groups II, III and IV respectively while group I received distilled water and served as the control group. At the end of extract administration, hematological analysis was carried out using the Automated Hematologic Analyzer. Result: Non-significant (p˃0.05) increase in PCV, RBC, WBC and Hemoglobin was recorded in groups II and III when compared with control group. There was significant increase (p<0.05) in PCV, RBC, WBC and Hemoglobin in group IV when compared with the control group. Conclusion: Spondias mombin may be useful in ameliorating the burden of dilutional anaemia in pregnancy.

Keywords: Spondias Mombin, Hematological Parameters, Pregnancy, Wistar Rats.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )