EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

FORMULATION DEVELOPMENT AND DISSOLUTION RATE ENHANCEMENT OF RILPIVIRINE BY SOLID DISPERSION SYSTEMS

Bharati Arali*, Anand Kumar Y., Mallikarjuna Setty C.

ABSTRACT

The aim of this study was to enhance the dissolution rate of rilpivirine (RPV) using solid dispersion systems. A comparison between kneading and solvent evaporation method was also investigated. Solid dispersions of rilpivirine were prepared using poloxamer 407 and HPC at 1:1 and 1:3 w/w ratios. Dissolution tests were conducted and evaluated on the basis of cumulative percentage drug release and dissolution efficiency. Physicochemical characterizations of the solid dispersions were carried out using Fourier transform infrared spectroscopy, differential scanning calorimetry and powder X‑ray diffraction. Dissolution was remarkably improved in both systems compared to pure rilpivirine (P<0.05). Physicochemical characterization results suggested that rilpivirine existed in the amorphous form in the entire solid dispersion systems providing evidence of improvement in dissolution. Formulations of rilpivirine solid dispersion systems prepared using poloxamer 407 by solvent evaporation method showed best dissolution profile and 1:3 were identified as an optimum drug‑polymer weight ratio. Further optimised formulations were prepared as direct compression tablets and evaluated for various parameters. The tablets were found to have desirable physical properties and showed good stability over the period of 6 months at 400±20C/75%±5%RH and 50±30C. Thus the present study demonstrated that poloxamer 407 as carrier and solvent evaporation technique is a highly effective strategy for enhancing the bioavailability of poorly water soluble rilpivirine.

Keywords: Solid dispersion, rilpivirine, dissolution enhancement, poloxamer 407, HPC.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )