IMPACT OF HMG COA REDUCTASE INHIBITORS ON THE GLYCEMIC STATUS OF NORMOGLYCEMIC INDIVIDUALS: A PROSPECTIVE, LONGITUIDINAL, OBSERVATIONAL STUDY

Subhayan Das, Dipan Saha*, Ram Narayan Maiti, Swarnali Paul, Sekhar Mandal

ABSTRACT

Background: HMG CoA reductase inhibitors (statins) are the most common drugs used for primary and secondary prevention of cardiovascular diseases. Various Clinical studies have suggested usage of long term statin therapy may lead to significant rise in the blood glucose levels of the patients. However the adequate and exact data regarding the impact of HMG CoA reductase inhibitors on glycemic status of Eastern Indian Population is still limited. Objective: To estimate the impact of HMG CoA reductase inhibitors on the glycemic status of euglycemic patients. Methods and Materials: An observational longitudinal study was carried out over 24 weeks at an Internal Medicine Outpatient Department of a tertiary care Hospital in Eastern India. Non diabetic Patients aged 30-65 years receiving HMG CoA reductase inhibitors were enrolled in our study. Patients with impaired fasting glucose and/or impaired glucose tolerance were excluded. FBS, PPBS, HbA1C and lipid profile of participants were monitored at baseline, at 12thweek and at 24th week. The data were analyzed accordingly by SPSS for the result. Result: The study population was predominantly male (64%), with mean age of 50.46± 9.65 years and mean weight of 70± 5.07kg. Majority of the patients were on Atorvastatin 20 mg. There were statistically significant rise of Mean FBS, Mean PPBS and Mean HbA1C at the end of 24 weeks. But since the values were within the normal clinical range, hence they were clinically insignificant. None of the patients developed New Onset Diabetes Mellitus at the end of 24 weeks. 3 out of 50 patients (6%) developed impaired blood glucose levels. Conclusion: Though Statins are the most common drugs used nowadays to prevent cardiovascular diseases, strict monitoring of blood glucose levels of the patients on statin therapy should be done at regular intervals.

Keywords: Statins, Dyslipidemia, Diabetes.