EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

IMPACT OF HMG COA REDUCTASE INHIBITORS ON THE GLYCEMIC STATUS OF NORMOGLYCEMIC INDIVIDUALS: A PROSPECTIVE, LONGITUIDINAL, OBSERVATIONAL STUDY

Subhayan Das, Dipan Saha*, Ram Narayan Maiti, Swarnali Paul, Sekhar Mandal

ABSTRACT

Background: HMG CoA reductase inhibitors (statins) are the most common drugs used for primary and secondary prevention of cardiovascular diseases. Various Clinical studies have suggested usage of long term statin therapy may lead to significant rise in the blood glucose levels of the patients. However the adequate and exact data regarding the impact of HMG CoA reductase inhibitors on glycemic status of Eastern Indian Population is still limited. Objective: To estimate the impact of HMG CoA reductase inhibitors on the glycemic status of euglycemic patients. Methods and Materials: An observational longitudinal study was carried out over 24 weeks at an Internal Medicine Outpatient Department of a tertiary care Hospital in Eastern India. Non diabetic Patients aged 30-65 years receiving HMG CoA reductase inhibitors were enrolled in our study. Patients with impaired fasting glucose and/or impaired glucose tolerance were excluded. FBS, PPBS, HbA1C and lipid profile of participants were monitored at baseline, at 12thweek and at 24th week. The data were analyzed accordingly by SPSS for the result. Result: The study population was predominantly male (64%), with mean age of 50.46± 9.65 years and mean weight of 70± 5.07kg. Majority of the patients were on Atorvastatin 20 mg. There were statistically significant rise of Mean FBS, Mean PPBS and Mean HbA1C at the end of 24 weeks. But since the values were within the normal clinical range, hence they were clinically insignificant. None of the patients developed New Onset Diabetes Mellitus at the end of 24 weeks. 3 out of 50 patients (6%) developed impaired blood glucose levels. Conclusion: Though Statins are the most common drugs used nowadays to prevent cardiovascular diseases, strict monitoring of blood glucose levels of the patients on statin therapy should be done at regular intervals.

Keywords: Statins, Dyslipidemia, Diabetes.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )