FORMULATION AND EVALUATION OF MUCOADHESIVE MICROSPHERES OF TERBUTALINE SULPHATE BY SOLVENT EVAPORATION METHOD

Khushboo Shriwas* and Niranjan S. K.

ABSTRACT

In the present study is regarding formulation and evaluation of terbutaline sulphate mucoadhesive microspheres by solvent evaporation method. The mucoadhesive microspheres were successfully developed by W/O emulsion solvent evaporation method. A total of nine formulations were prepared I.e MM1, MM2, MM3, MM4, MM5, MM6, MM7, MM8 and MM9. The particle size of all the formulations were ranged between 128.80±11.12 and 152.42±17.13. The entrapment efficacy was ranged between 71.54 And 64.48. Based on above parameters three formulation were selected I.e MM3, MM5 and MM8 for further studies like micromeritic property swelling index and in vitro release study. The optimized batch MM3 was found to release the drug for 16h (94.4%) and follows higuchi matrix model and korsmeyer-peppas equation in dissolution study. Stability studies showed almost negligible changes in particle size, entrapment efficiency and drug release throughout the study period.

Keywords: Terbutaline sulphate, microspheres, Higuchi model, korsmeyer-peppas equation and stability studies.