EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Scope Database , Academia , 

 ISSN 2394-3211

Impact Factor: 7.065

 ICV - 79.57

Abstract

ANTIOXIDANT ACTIVITY OF SENECIO AMPLEXICAULIS KUNTH. ESSENTIAL OIL GROWING IN HIGH-ALTITUDE HIMALAYAN REGION

Rajendra Singh, Vivek Ahluwalia, Nitin Sati*

ABSTRACT

Objective: Senecio amplexicaulis Kunth. Syn Ligularia amplexicaulis DC (Asteraceae), a deciduous shrub found in north-west (Garhwal) Himalayas of Uttarakhand (India) was collected at an altitude of around 3000 m. Light pale yellow essential oil (0.66% w/v) of S. amplexicaulis Kunth., obtained by hydro-distillation of roots was evaluated for antioxidant potential. Methods: The antioxidant and free radical activity of S.amplexicaulis essential oil was investigated by assessing its effect on linoleic acid peroxidation and ability to scavenge DPPH and ABTS free radicals. Results: The essential oil exhibited noticeable antioxidant activity in all the assays. The scavenging ability for DPPH free radicals was dose dependent with IC50 value of 81.6μg/ml. The oil inhibited 44.8% of the ABTS radical cations at 100μg/ml. The oil also exhibited concentration dependent effect on inhibition of lipid peroxidation. After 30h, essential oil produced 71% inhibition of lipid peroxidation at 100μg/ml, when compared to control. The antioxidant potential of essential oil was however low when compared to synthetic antioxidant, butylated hydroxy toluene. Conclusion: The present study reveals noticeable antioxidant potential of essential oil extracted from Senecio amplexicaulis Kunth. and suggests a need for further exploration.

Keywords: Senecio, lipid peroxidation, free radical, Asteraceae.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database Academia