EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

CLINICAL IMPACTS OF ST- SEGMENT NON-RESOLUTION AFTER THROMBOLYSIS FOR MYOCARDIAL INFARCTION

*Dr. Kiran Yadav and Dr. Ranjana Mandal

ABSTRACT

Objectives: We investigated the clinical consequences of non-resolution of the ST segment after thrombolytic therapy for acute ST-elevation myocardial infarction, in 100 consecutive patients admitted to a coronary care unit. Failed thrombolysis was defined as <50% ST-segment resolution at 90 minutes after the start of thrombolytic treatment. Outcomes were measured in terms of in hospital adverse events and mortality at 6 weeks. Material And Methods: A total of 100 patients with first episode of ST elevation myocardial infarction without any conventional contraindication for thrombolysis were taken for the study. % of ST segment resolution after 90 min of thrombolysis was calculated and correlation with Ttn, ejection fration, arrhythmia, prognosis in the patients with acute Myocardial Infarction. Results: Out of 100 patients who were thrombolysed, 30% had failed thrombolysis. Patient who presented within 6 hours of chest pain had 7.7% failed thrombolysis which was significantly lower than patients who presented >6 hrs of chest pain with 44.5% failure rate, p value 0.0002. patients with positive troponin T on admission were having high thrombolysis failure 40.8% as compared to 17.4% failure rate in patients with negative troponin T on admission p value 0.0203. Conclusion: Long symptom to needle time is an important predictor of failed thrombolysis in acute myocardial infarction patients. Persistence of chest pain beyond 2 hours and non-resolution of reciprocal ST depression can serve as additional markers of failed thrombolysis. As failed thrombolysis can be associated with poor prognosis its recognition and appropriate further management is needed.

Keywords: Acute Coronary Syndrome (CAD), ST segment elevation, ST segment resolution, Thrombolysis.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )